Table 1.
Patient and donor characteristics at baseline (FAS)
| Parameter | Arm 1 (n = 283) | Arm 2 (n = 287) | Arm 3 (n = 274) |
|---|---|---|---|
| Patient characteristics | |||
| Age, years* | 54.3 (9.1) | 54.0 (9.7) | 53.7 (10.6) |
| Gender, n (%) | |||
| Male | 201 (71.3) | 203 (70.7) | 190 (69.3) |
| Female | 81 (28.7) | 84 (29.3) | 84 (30.7) |
| Not recorded | 1 | 0 | 0 |
| Race, n (%) | |||
| Caucasian | 272 (96.5) | 269 (93.7) | 257 (93.8) |
| Black/African | 1 (0.4) | 7 (2.4) | 7 (2.6) |
| Asian | 1 (0.4) | 2 (0.7) | 2 (0.7) |
| Other | 8 (2.8) | 9 (3.1) | 8 (2.9) |
| Not recorded | 1 | 0 | 0 |
| Weight, kg† | 77.0 (16.6) | 78.0 (17.0) | 78.1 (16.2) |
| BMI, kg/m2 ‡ | 26.2 (4.9) | 26.5 (5.4) | 26.7 (4.7) |
| Viral status at baseline, n (%) | |||
| HIV‐negative | 278 (98.6) | 285 (99.3) | 267 (97.4) |
| HIV unknown | 4 (1.4) | 2 (0.7) | 7 (2.6) |
| HIV not recorded | 1 | 0 | 0 |
| HCV‐positive | 88 (31.2) | 77 (26.8) | 77 (28.1) |
| HCV‐negative | 192 (68.1) | 208 (72.5) | 196 (71.5) |
| HCV unknown | 2 (0.7) | 2 (0.7) | 1 (0.4) |
| HCV not recorded | 1 | 0 | 0 |
| Primary diagnosis for transplantation, n (%) | |||
| Cirrhosis | 209 (73.9) | 224 (78.0) | 197 (71.9) |
| Hepatocellular carcinoma | 88 (31.1) | 79 (27.5) | 84 (30.7) |
| Budd–Chiari syndrome | 2 (0.7) | 2 (0.7) | 1 (0.4) |
| Metabolic disease | 5 (1.8) | 4 (1.4) | 11 (4.0) |
| Sclerosing cholangitis | 15 (5.3) | 21 (7.3) | 20 (7.3) |
| Other | 28 (9.9) | 18 (6.3) | 18 (6.6) |
| eGFR (MDRD4)§, mL/min/1.73m2 | 90.6 (39.1) | 89.3 (40.7) | 89.9 (34.6) |
| Number of patients on dialysis pre‐transplant | 6 | 9 | 3 |
| MELD scoreǁ | |||
| < 25 | 14.2 (5.3) | 14.6 (4.9) | 14.0 (4.9) |
| ≥ 25 | 31.4 (5.3) | 31.4 (4.7) | 29.6 (3.9) |
| Cold ischemia time¶, hours | 6.7 (3.1) | 6.7 (2.5) | 6.6 (2.7) |
| Donor characteristics | |||
| Age, years** | 51.2 (17.5) | 50.5 (18.5) | 51.3 (18.0) |
| Gender, n (%) | |||
| Male | 158 (56.0) | 168 (58.5) | 144 (52.6) |
| Female | 124 (44.0) | 119 (41.5) | 130 (47.4) |
| Not recorded | 1 | 0 | 0 |
| Race, n (%) | |||
| Caucasian | 159 (56.4) | 161 (56.1) | 152 (55.5) |
| Black/African | 3 (1.1) | 0 | 1 (0.4) |
| Asian | 1 (0.4) | 4 (1.4) | 0 |
| Other | 119 (42.2) | 122 (42.5) | 121 (44.2) |
| Not recorded | 1 | 0 | 0 |
| Type of donor, n (%) | |||
| Living, related | 5 (1.8) | 5 (1.7) | 6 (2.2) |
| Living, nonrelated | 2 (0.7) | 1 (0.3) | 2 (0.7) |
| Deceased | 275 (97.5) | 281 (97.9) | 266 (97.1) |
| Not recorded | 1 | 0 | 0 |
Results are shown as mean (SD) unless otherwise indicated. Patients with missing baseline data were excluded from these analyses for Arms 1–3, respectively: *n = 282, n = 287, n = 274; †n = 281, n = 286, n = 270; ‡n = 280, n = 285, n = 269; §n = 281, n = 285 and n = 271; ǁMELD was calculated retrospectively; MELD < 25: n = 239, n = 238 and n = 217; MELD ≥ 25: n = 29, n = 35, n = 35; ¶n = 238, n = 243, n = 228; **n = 282, n = 287, n = 273.
eGFR, estimated glomerular filtration rate; FAS, full‐analysis set; HCV, hepatitis C virus; HIV, human immunodeficiency virus; MELD, Model of End‐stage Liver Disease; MDRD4, Modification of Diet in Renal Disease‐4; SD, standard deviation.