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Pharmacokinetic modeling of (a) simulated concentrations of SMT C1100 in plasma and tissue and (b) predicted vs. observed concentrations in plasma, both after repeat dosing with SMT C1100 100 mg/kg bid. In (a) the predicted level required to achieve in vitro EC50 concentrations (0.2 μM/67 ng/mL) is depicted by the dashed line.
