Table 2. Univariate Analyses of Factors Associated with Overall Survival and Time to Recurrence.
| Variable | Overall Survival |
Time to Recurrence |
||
|---|---|---|---|---|
| Hazard ratio (95% CI) | p Value | Hazard ratio (95% CI) | p Value | |
| Sex (male vs. female) | 0.791(0.428–1.460) | NS | 0.850(0.454–1.427) | NS |
| Age, y (>52 vs. ≤52) | 1.061(0.645–1.745) | NS | 1.177(0.734–1.887) | NS |
| AFP (ng/ml; >20 vs. ≤20) | 1.235(0.741–2.060) | NS | 1.152(0.713–1.863) | NS |
| Liver cirrhosis (yes vs. no) | 1.627(0.701–3.777) | NS | 1.388(0.663–2.902) | NS |
| ALT (units/L; >75 vs ≤75) | 1.530(0.697–3.362) | NS | 1.138(0.492–2.630) | NS |
| Tumor size (cm; >5 vs. ≤5) | 1.732(1.028–2.917) | 0.039 | 2.115(1.295–3.454) | 0.003 |
| Tumor number (multiple vs. single) | 2.040 (1.034–4.026) | 0.040 | 1.936 (1.010–3.708) | 0.046 |
| Vascular invasion (yes vs. no) | 2.351 (1.423–3.883) | 0.001 | 2.286 (1.416–3.691) | 0.001 |
| TNM stage (II/III vs. I) | 2.351 (1.423–3.883) | 0.001 | 2.273 (1.422–3.189) | 0.001 |
| Tumor differentiation (III/IV vs. I/II) | 1.459 (0.855–2.490) | 0.166 | 1.467 (0.887–2.427) | NS |
| Tumor encapsulation (none vs. complete) | 1.170 (0.711–1.926) | 0.536 | 1.268 (0.790–2.034) | NS |
| STYK1(high vs. low) | 2.479 (1.476–4.161) | 0.001 | 2.582 (1.573–2.238) | <0.001 |
NOTE: Univariate analysis, Cox proportional hazards regression model.
Abbreviation: 95% CI, 95% confidence interval; AFP, alpha-fetoprotein; NS, not significant(Cox proportional hazards regression model); TNM, tumor-node-metastasis.