Table 1. The ratios of morphine to M3G and M6G to M3G were calculated after determined these compounds in acute morphine tolerance mice plasma, cerebrums and epencephalons with or without brain OATP2B1 inhibition.
| Group | Tolerance + DGL-PEG/dermorphin |
Tolerance + DGL-PEG/dermorphin/siRNA (OATP2B1) |
||
|---|---|---|---|---|
| [Morphine/M3G] | [M6G/M3G] | [Morphine/M3G] | [M6G/M3G] | |
| Plasma | 2.17 ± 0.59 | 2.01 ± 0.55 | 1.46 ± 0.23 | 0.97 ± 0.22 |
| Cerebrum | 0.89 ± 0.11 | 0.64 ± 0.17 | 0.34 ± 0.10 | 0.27 ± 0.07 |
| Epencephalon | 1.33 ± 0.45 | 1.62 ± 0.46 | 0.71 ± 0.10 | 0.60 ± 0.15 |
(Data are the mean ± SEM of 6 independent determinations).