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Bioequivalence of effervescent N-acetylcysteine (NAC) tablets and oral solution NAC for prespecified pharmacokinetic parameters.
| Parameter | Effervescent NAC tablets (LSM) | Reference oral solution NAC (LSM) | Ratio (% reference product) | 90% CI | ANOVA %CV |
|---|---|---|---|---|---|
| AUC0–∞ (h × μg/mL) | 177.31 | 192.15 | 92.28 | 86.39–98.56 | 14.81 |
| AUC0–last (h × μg/mL) | 170.90 | 185.54 | 92.11 | 86.18–98.44 | 14.94 |
| Cmax (μg/mL) | 25.44 | 27.46 | 92.64 | 86.84–98.84 | 14.54 |
LSM = least squares mean.
