Table IV.
Subject preference survey results for formulation attributes.*
| Attribute | Effervescent NAC tablets (n = 29) | Reference oral solution NAC (n = 30) | P value† |
|---|---|---|---|
| Taste | 0.0247 | ||
| Like very much | 1 (3.4) | 0 | |
| Like | 7 (24.1) | 0 | |
| Neither like nor dislike | 5 (17.2) | 4 (13.3) | |
| Dislike | 7 (24.1) | 20 (66.7) | |
| Dislike very much | 9 (31.0) | 6 (20.0) | |
| Smell | 0.0533 | ||
| Like very much | 1 (3.4) | 0 | |
| Like | 5 (17.2) | 1 (3.3) | |
| Neither like nor dislike | 5 (17.2) | 7 (23.3) | |
| Dislike | 12 (41.4) | 14 (46.7) | |
| Dislike very much | 6 (20.7) | 8 (26.7) | |
| Flavor | 0.0082 | ||
| Like very much | 0 | 0 | |
| Like | 8 (27.61) | 0 | |
| Neither like nor dislike | 6 (20.7) | 4 (13.3) | |
| Dislike | 7 (24.1) | 19 (63.3) | |
| Dislike very much | 8 (27.6) | 7 (23.3) | |
| Texture | 0.0090 | ||
| Like very much | 1 (3.4) | 0 | |
| Like | 7 (24.1) | 4 (13.3) | |
| Neither like nor dislike | 18 (62.1) | 15 (50.0) | |
| Dislike | 2 (6.9) | 8 (26.7) | |
| Dislike very much | 1 (3.4) | 3 (10.0) | |
| Overall likeability | 0.0012 | ||
| Like very much | 2 (6.9) | 0 | |
| Like | 7 (24.1) | 0 | |
| Neither like nor dislike | 9 (31.0) | 6 (20.0) | |
| Dislike | 5 (17.2) | 18 (60.0) | |
| Dislike very much | 6 (20.7) | 6 (20.0) |
NAC = N-acetylcysteine.
⁎
Values are presented as number (%). One subject discontinued during Period 2 without receiving the Period 2 treatment (effervescent NAC tablets).
†
Wilcoxon signed rank test.