Fig. 3.

TDO2 deficiency is associated with minimal change in exploratory activity as measured by percentage of total visit frequency after 5 h of free adaptation during the light phase of R1. Percent visits with nosepokes after 5 h of exploration in the light phase during R1 (a) and R2 (b) was not significantly different between WT and GKO mice. A significant genotype effect on percent visits with licks after 5 h of diurnal exploration was observed in R1 (c), but not in R2 (d). Deficiency of TDO2 did not affect percent visits with nosepokes after 5 h of nocturnal exploration in R1 (e) and R2 (f). A significant genotype effect also was not observed in either R1 (g) or R2 (h) in terms of percent visits with licks during the dark phase (d, h). Data are mean±SEM. *p<0.05, unpaired t-test with Welch׳s correction in the event of unequal variances. Total n=18 WT and n=17 GKO mice.