Fig. 8.

Corner visit frequency of IDO2 WT and GKO mice during drinking and non-drinking sessions in R1 and R2. During the drinking sessions, IDO2 WT mice significantly increased their corner visits in the first day while retaining the same level of corner visits for the next day in both R1 (a) and R2 (b). No significant genotype effect was observed between WT and GKO mice. (c) During non-drinking sessions, both WT and GKO mice significantly increased corner visits only on the first day in R1. (d) However, in R2 they significantly reduced visit activity on the next day, suggesting learned behavior. The visit frequency of test day 1 or 2 was compared to that on the previous day by repeated contrast. *p<0.05, **p<0.01, ***p<0.001, repeated contrast. The data (mean±SEM) showed no significant genotype effect at each level of repeated contrast. Total n=16 WT and n=15 GKO mice.