Table 2. Gene Ontology (GO) pathway analysis of Y-hg O3e^* interacted SNPs.

Index	Pathway enrichment	P	PFDR
1	Tob1 Pathway	<0.001	<0.001
2	Hematopoietin interferon classd200 domain cytokine receptor binding (GO:0005126)	<0.001	<0.001
3	Homeostasis of number of cells (GO:0048872)	0.001	0.003
4	Natural killer cell activation (GO:0030101)	<0.001	0.003
5	IL18 Pathway	<0.001	0.003
6	Lymphocyte activation (GO:0046649)	<0.001	0.006
7	Cell activation (GO:0001775)	0.001	0.007
8	Antigen processing and presentation of endogenous peptide antigen (GO:0002483)	0.001	0.007
9	Positive regulation of mononuclear cell proliferation (GO:0032946)	0.001	0.008
10	Lymphocyte proliferation (GO:0046651)	<0.001	0.008
11	Leukocyte activation (GO:0045321)	0.001	0.009
12	Regulation of cell growth (GO:0001558)	0.006	0.023
13	Antigen processing and presentation of peptide antigen via MHC class i (GO:0002474)	0.005	0.025
14	Regulation of mononuclear cell proliferation (GO:0032944)	0.007	0.031
15	T cell homeostasis (GO:0043029)	0.017	0.032
16	Regulation of blood pressure (GO:0008217)	0.010	0.034
17	Lymphocyte mediated immunity (GO:0002449)	0.017	0.044