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. 2016 Aug 16;9:262–270. doi: 10.1016/j.dib.2016.08.019

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© 2016 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Fig. 1 — (A) Percent difference estimates for a 10-year difference in age for each biomarker, adjusted for MACS study site and time of day of blood draw. Blue circles represent the percent difference in biomarker concentrations for a 10-year difference in age. For example, a percent difference of 18 for CXCL10 indicates that a 10-year increase in age is associated with 18% higher concentrations of CXCL10. The red line indicates unity, i.e., no relative difference in biomarker concentrations. Filled markers represent statistical significance (P<0.002). (B) Percent difference estimates in biomarker concentrations for non-blacks vs. blacks, adjusted for age, MACS study site, and time of day of blood draw. Blue circles represent the percent difference in biomarker concentrations for non-blacks relative to blacks. The red line indicates unity, i.e., no relative difference in biomarker concentrations. Filled markers represent statistical significance (P<0.002). (C) Percent difference estimates in biomarker concentrations for overweight BMI vs. normal BMI, adjusted for age, MACS study site, and time of day of blood draw. Blue circles represent the percent difference in each biomarker concentration between men with overweight BMI relative to men with normal BMI. The red line indicates unity, i.e., no relative difference in biomarker concentrations. Filled markers represent statistical significance (P<0.002). (D) Percent difference estimates in biomarker concentrations for obese BMI vs. normal BMI, adjusted for age, MACS study site, and time of day of blood draw. Blue circles represent the percent difference in biomarker concentrations for men with obese BMI relative to men with normal BMI. The red line indicates unity, i.e., no relative difference in biomarker concentrations. Filled markers represent statistical significance (P<0.002). (E) Percent difference estimates in biomarker concentrations for those with cleared hepatitis C infection (antibody+ only) vs. those who are not infected with hepatitis C, adjusted for age, MACS study site, and time of day of blood draw. Blue circles represent the percent difference in biomarker concentrations for men with cleared hepatitis C infection (antibody + only) relative to those without hepatitis C infection. The red line indicates unity, i.e., no relative difference in biomarker concentrations. Filled markers represent statistical significance (P<0.002). (F) Percent difference estimates in biomarker concentrations for those with chronic hepatitis C infection vs. those who are not infected with hepatitis C, adjusted for age, MACS study site, and time of day of blood draw. Blue circles represent the percent difference in biomarker concentrations for men with chronic HCV relative to those without HCV. The red line indicates unity, i.e., no relative difference in biomarker concentrations. Filled markers represent statistical significance (P<0.002). (G) Percent difference estimates in biomarker concentrations for former smokers vs. never smokers, adjusted for age, MACS study site, and time of day of blood draw. Blue circles represent the percent difference in biomarker concentrations for former smokers relative to never smokers. The red line indicates unity, i.e., no relative difference in biomarker concentrations. Filled markers represent statistical significance (P<0.002). (H) Percent difference estimates in biomarker concentrations for current smokers vs. never smokers, adjusted for age, MACS study site, and time of day of blood draw. Blue circles represent the percent difference in biomarker concentrations for current smokers relative to never smokers. The red line indicates unity, i.e., no relative difference in biomarker concentrations. Filled markers represent statistical significance (P<0.002). (I) Percent difference estimates in biomarker concentrations for moderate-heavy alcohol consumption vs. no alcohol consumption since last visit, adjusted for age, MACS study site, and time of day of blood draw. Blue circles represent the percent difference in biomarker concentration for moderate-heavy alcohol consumption relative to no alcohol consumption. The red line indicates unity, i.e., no relative difference in biomarker concentrations. Filled markers represent statistical significance (P<0.002). (J) Percent difference estimates in biomarker concentrations for binge alcohol consumption vs. no alcohol consumption since last visit, adjusted for age, MACS study site, and time of day of blood draw. Blue circles represent the percent difference in biomarker concentration for binge alcohol consumption relative to no alcohol consumption. The red line indicates unity, i.e., no relative difference in biomarker concentrations. Filled markers represent statistical significance (P<0.002). (K) Percent difference estimates in biomarker concentrations for marijuana use vs. no marijuana use since last visit, adjusted for age, MACS study site, and time of day of blood draw. Blue circles represent the percent difference in biomarker concentration for use of marijuana vs. no use of marijuana. The red line indicates unity, i.e., no relative difference in biomarker concentrations. Filled markers represent statistical significance (P<0.002). (L) Percent difference estimates in biomarker concentrations for use of amyl nitrates vs. no use of amyl nitrates since last visit, adjusted for age, MACS study site, and time of day of blood draw. Blue circles represent the percent difference in biomarker concentrations for use of amyl nitrates relative to no use of amyl nitrates. The red line indicates unity, i.e., no relative difference in biomarker concentrations. Filled markers represent statistical significance (P<0.002). (M) Percent difference estimates in biomarker concentrations for use of stimulants vs. no use of stimulants since last visit, adjusted for age, MACS study site, and time of day of blood draw. Blue circles represent the percent difference in biomarker concentration for use of stimulants relative to no use of stimulants. The red line indicates unity, i.e., no relative difference in biomarker concentrations. Filled markers represent statistical significance (P<0.002). (N) Percent difference estimates in biomarker concentrations for depressive symptoms, adjusted for age, MACS study site, and time of day of blood draw. Blue circles represent the percent difference in biomarker concentrations for presence of depressive symptoms (CES-D ≥ 16 only) relative to no presence of depressive symptoms. The red line indicates unity, i.e., no relative difference in biomarker concentrations. Filled markers represent statistical significance (P<0.002). (O) Percent difference estimates in biomarker concentrations for depression, adjusted for age, MACS study site, and time of day of blood draw. Blue circles represent the percent difference in biomarker concentrations for depression (CES-D≥16 or self-reported use of depression medication) relative to no depression. The red line indicates unity, i.e., no relative difference in biomarker concentrations. Filled markers represent statistical significance (P<0.002). (P) Percent difference estimates in biomarker concentrations for persistent diabetes, adjusted for age, MACS study site, and time of day of blood draw. Blue circles represent the percent difference in biomarker concentrations for men with persistent diabetes relative to those without persistent diabetes. The red line indicates unity, i.e., no relative difference in biomarker concentrations. Filled markers represent statistical significance (P<0.002). (Q) Percent difference estimates in biomarker concentrations for persistent hypertension, adjusted for age, MACS study site, and time of day of blood draw. Blue circles represent the percent difference in biomarker concentrations for men with persistent hypertension relative to those without persistent hypertension. The red line indicates unity, i.e., no relative difference in biomarker concentrations. Filled markers represent statistical significance (P<0.002). (R) Percent difference estimates in biomarker concentrations for hypercholesterolemia, adjusted for age, MACS study site, and time of day of blood draw. Blue circles represent the percent difference in biomarker concentration for men with hypercholesterolemia relative to men without hypercholesterolemia. The red line indicates unity, i.e., no relative difference in biomarker concentrations. Filled markers represent statistical significance (P<0.002) (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article).

Fig. 1 — (A) Percent difference estimates for a 10-year difference in age for each biomarker, adjusted for MACS study site and time of day of blood draw. Blue circles represent the percent difference in biomarker concentrations for a 10-year difference in age. For example, a percent difference of 18 for CXCL10 indicates that a 10-year increase in age is associated with 18% higher concentrations of CXCL10. The red line indicates unity, i.e., no relative difference in biomarker concentrations. Filled markers represent statistical significance (P<0.002). (B) Percent difference estimates in biomarker concentrations for non-blacks vs. blacks, adjusted for age, MACS study site, and time of day of blood draw. Blue circles represent the percent difference in biomarker concentrations for non-blacks relative to blacks. The red line indicates unity, i.e., no relative difference in biomarker concentrations. Filled markers represent statistical significance (P<0.002). (C) Percent difference estimates in biomarker concentrations for overweight BMI vs. normal BMI, adjusted for age, MACS study site, and time of day of blood draw. Blue circles represent the percent difference in each biomarker concentration between men with overweight BMI relative to men with normal BMI. The red line indicates unity, i.e., no relative difference in biomarker concentrations. Filled markers represent statistical significance (P<0.002). (D) Percent difference estimates in biomarker concentrations for obese BMI vs. normal BMI, adjusted for age, MACS study site, and time of day of blood draw. Blue circles represent the percent difference in biomarker concentrations for men with obese BMI relative to men with normal BMI. The red line indicates unity, i.e., no relative difference in biomarker concentrations. Filled markers represent statistical significance (P<0.002). (E) Percent difference estimates in biomarker concentrations for those with cleared hepatitis C infection (antibody+ only) vs. those who are not infected with hepatitis C, adjusted for age, MACS study site, and time of day of blood draw. Blue circles represent the percent difference in biomarker concentrations for men with cleared hepatitis C infection (antibody + only) relative to those without hepatitis C infection. The red line indicates unity, i.e., no relative difference in biomarker concentrations. Filled markers represent statistical significance (P<0.002). (F) Percent difference estimates in biomarker concentrations for those with chronic hepatitis C infection vs. those who are not infected with hepatitis C, adjusted for age, MACS study site, and time of day of blood draw. Blue circles represent the percent difference in biomarker concentrations for men with chronic HCV relative to those without HCV. The red line indicates unity, i.e., no relative difference in biomarker concentrations. Filled markers represent statistical significance (P<0.002). (G) Percent difference estimates in biomarker concentrations for former smokers vs. never smokers, adjusted for age, MACS study site, and time of day of blood draw. Blue circles represent the percent difference in biomarker concentrations for former smokers relative to never smokers. The red line indicates unity, i.e., no relative difference in biomarker concentrations. Filled markers represent statistical significance (P<0.002). (H) Percent difference estimates in biomarker concentrations for current smokers vs. never smokers, adjusted for age, MACS study site, and time of day of blood draw. Blue circles represent the percent difference in biomarker concentrations for current smokers relative to never smokers. The red line indicates unity, i.e., no relative difference in biomarker concentrations. Filled markers represent statistical significance (P<0.002). (I) Percent difference estimates in biomarker concentrations for moderate-heavy alcohol consumption vs. no alcohol consumption since last visit, adjusted for age, MACS study site, and time of day of blood draw. Blue circles represent the percent difference in biomarker concentration for moderate-heavy alcohol consumption relative to no alcohol consumption. The red line indicates unity, i.e., no relative difference in biomarker concentrations. Filled markers represent statistical significance (P<0.002). (J) Percent difference estimates in biomarker concentrations for binge alcohol consumption vs. no alcohol consumption since last visit, adjusted for age, MACS study site, and time of day of blood draw. Blue circles represent the percent difference in biomarker concentration for binge alcohol consumption relative to no alcohol consumption. The red line indicates unity, i.e., no relative difference in biomarker concentrations. Filled markers represent statistical significance (P<0.002). (K) Percent difference estimates in biomarker concentrations for marijuana use vs. no marijuana use since last visit, adjusted for age, MACS study site, and time of day of blood draw. Blue circles represent the percent difference in biomarker concentration for use of marijuana vs. no use of marijuana. The red line indicates unity, i.e., no relative difference in biomarker concentrations. Filled markers represent statistical significance (P<0.002). (L) Percent difference estimates in biomarker concentrations for use of amyl nitrates vs. no use of amyl nitrates since last visit, adjusted for age, MACS study site, and time of day of blood draw. Blue circles represent the percent difference in biomarker concentrations for use of amyl nitrates relative to no use of amyl nitrates. The red line indicates unity, i.e., no relative difference in biomarker concentrations. Filled markers represent statistical significance (P<0.002). (M) Percent difference estimates in biomarker concentrations for use of stimulants vs. no use of stimulants since last visit, adjusted for age, MACS study site, and time of day of blood draw. Blue circles represent the percent difference in biomarker concentration for use of stimulants relative to no use of stimulants. The red line indicates unity, i.e., no relative difference in biomarker concentrations. Filled markers represent statistical significance (P<0.002). (N) Percent difference estimates in biomarker concentrations for depressive symptoms, adjusted for age, MACS study site, and time of day of blood draw. Blue circles represent the percent difference in biomarker concentrations for presence of depressive symptoms (CES-D ≥ 16 only) relative to no presence of depressive symptoms. The red line indicates unity, i.e., no relative difference in biomarker concentrations. Filled markers represent statistical significance (P<0.002). (O) Percent difference estimates in biomarker concentrations for depression, adjusted for age, MACS study site, and time of day of blood draw. Blue circles represent the percent difference in biomarker concentrations for depression (CES-D≥16 or self-reported use of depression medication) relative to no depression. The red line indicates unity, i.e., no relative difference in biomarker concentrations. Filled markers represent statistical significance (P<0.002). (P) Percent difference estimates in biomarker concentrations for persistent diabetes, adjusted for age, MACS study site, and time of day of blood draw. Blue circles represent the percent difference in biomarker concentrations for men with persistent diabetes relative to those without persistent diabetes. The red line indicates unity, i.e., no relative difference in biomarker concentrations. Filled markers represent statistical significance (P<0.002). (Q) Percent difference estimates in biomarker concentrations for persistent hypertension, adjusted for age, MACS study site, and time of day of blood draw. Blue circles represent the percent difference in biomarker concentrations for men with persistent hypertension relative to those without persistent hypertension. The red line indicates unity, i.e., no relative difference in biomarker concentrations. Filled markers represent statistical significance (P<0.002). (R) Percent difference estimates in biomarker concentrations for hypercholesterolemia, adjusted for age, MACS study site, and time of day of blood draw. Blue circles represent the percent difference in biomarker concentration for men with hypercholesterolemia relative to men without hypercholesterolemia. The red line indicates unity, i.e., no relative difference in biomarker concentrations. Filled markers represent statistical significance (P<0.002) (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article).