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. Author manuscript; available in PMC: 2017 Apr 15.
Published in final edited form as: Stat Med. 2015 Oct 5;35(8):1299–1314. doi: 10.1002/sim.6754

Table 1.

Simulation results for comparison of AUC, AARD, and MRD from JM2 to the other 3 models under simulation Scenario 1. Percent gain and estimated percent gain are calculated as (JM2−JM1)/True and (JM2−JM1)/JM2 respectively.

Cox (baseline) Cox (time-dependent) JM1 JM2 % gain (JM2 vs JM1)





t True Mean ESD Mean ESD Mean ESD Mean ESD True Estimated
AUC
3 0.659 0.634 0.028 0.501 0.031 0.624 0.029 0.649 0.028 0.038 0.039
3.5 0.673 0.643 0.026 0.497 0.029 0.634 0.028 0.662 0.027 0.042 0.042
4 0.692 0.657 0.026 0.497 0.028 0.644 0.027 0.679 0.027 0.051 0.052
4.5 0.715 0.672 0.026 0.496 0.029 0.657 0.025 0.699 0.025 0.059 0.06
5 0.745 0.691 0.027 0.499 0.032 0.676 0.026 0.725 0.025 0.066 0.068
AARD
3 0.230 0.198 0.048 0.013 0.054 0.180 0.051 0.219 0.048 0.17 0.178
3.5 0.252 0.210 0.045 −0.002 0.050 0.194 0.051 0.237 0.048 0.171 0.181
4 0.281 0.232 0.045 −0.018 0.049 0.211 0.047 0.262 0.048 0.181 0.195
4.5 0.316 0.255 0.043 −0.036 0.052 0.226 0.047 0.293 0.048 0.212 0.229
5 0.363 0.283 0.048 −0.043 0.055 0.254 0.047 0.331 0.044 0.212 0.233
MRD
3 0.065 0.044 0.015 0.003 0.013 0.028 0.009 0.055 0.014 0.415 0.491
3.5 0.088 0.058 0.018 0.000 0.016 0.040 0.011 0.075 0.017 0.398 0.467
4 0.113 0.073 0.020 −0.002 0.018 0.052 0.013 0.096 0.020 0.389 0.458
4.5 0.134 0.084 0.022 −0.004 0.019 0.062 0.014 0.114 0.021 0.388 0.456
5 0.147 0.088 0.022 −0.002 0.020 0.069 0.014 0.125 0.021 0.381 0.448