Table 1.
Cox (baseline) | Cox (time-dependent) | JM1 | JM2 | % gain (JM2 vs JM1) | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|
t | True | Mean | ESD | Mean | ESD | Mean | ESD | Mean | ESD | True | Estimated |
AUC | |||||||||||
3 | 0.659 | 0.634 | 0.028 | 0.501 | 0.031 | 0.624 | 0.029 | 0.649 | 0.028 | 0.038 | 0.039 |
3.5 | 0.673 | 0.643 | 0.026 | 0.497 | 0.029 | 0.634 | 0.028 | 0.662 | 0.027 | 0.042 | 0.042 |
4 | 0.692 | 0.657 | 0.026 | 0.497 | 0.028 | 0.644 | 0.027 | 0.679 | 0.027 | 0.051 | 0.052 |
4.5 | 0.715 | 0.672 | 0.026 | 0.496 | 0.029 | 0.657 | 0.025 | 0.699 | 0.025 | 0.059 | 0.06 |
5 | 0.745 | 0.691 | 0.027 | 0.499 | 0.032 | 0.676 | 0.026 | 0.725 | 0.025 | 0.066 | 0.068 |
AARD | |||||||||||
3 | 0.230 | 0.198 | 0.048 | 0.013 | 0.054 | 0.180 | 0.051 | 0.219 | 0.048 | 0.17 | 0.178 |
3.5 | 0.252 | 0.210 | 0.045 | −0.002 | 0.050 | 0.194 | 0.051 | 0.237 | 0.048 | 0.171 | 0.181 |
4 | 0.281 | 0.232 | 0.045 | −0.018 | 0.049 | 0.211 | 0.047 | 0.262 | 0.048 | 0.181 | 0.195 |
4.5 | 0.316 | 0.255 | 0.043 | −0.036 | 0.052 | 0.226 | 0.047 | 0.293 | 0.048 | 0.212 | 0.229 |
5 | 0.363 | 0.283 | 0.048 | −0.043 | 0.055 | 0.254 | 0.047 | 0.331 | 0.044 | 0.212 | 0.233 |
MRD | |||||||||||
3 | 0.065 | 0.044 | 0.015 | 0.003 | 0.013 | 0.028 | 0.009 | 0.055 | 0.014 | 0.415 | 0.491 |
3.5 | 0.088 | 0.058 | 0.018 | 0.000 | 0.016 | 0.040 | 0.011 | 0.075 | 0.017 | 0.398 | 0.467 |
4 | 0.113 | 0.073 | 0.020 | −0.002 | 0.018 | 0.052 | 0.013 | 0.096 | 0.020 | 0.389 | 0.458 |
4.5 | 0.134 | 0.084 | 0.022 | −0.004 | 0.019 | 0.062 | 0.014 | 0.114 | 0.021 | 0.388 | 0.456 |
5 | 0.147 | 0.088 | 0.022 | −0.002 | 0.020 | 0.069 | 0.014 | 0.125 | 0.021 | 0.381 | 0.448 |