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. 2016 Sep 15;47:88. doi: 10.1186/s13567-016-0375-4

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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IHC labelling of PrP ^CWD using F89/160.1.5 and 2G11 mAb. A Obex, intense coarse particulate labelling in the DMNV ×200. B Cerebellum, patchy labelling in the granular layer and stellate in the molecular layer ×200. C Ventral midbrain, scattered granules or accumulations of PrP^CWD that appear as plaques ×400. D Ventral midbrain, neuronal and axonal labelling ×400. E Ventral midbrain, linear type labelling ×100. F Dorsal midbrain, sparse immunolabelling, plaque-like accumulation of PrP^CWD ×100.