Table 3.
miRNA | Biological sample | Consequences | Refs. | |
---|---|---|---|---|
miRNAs associated with positive outcome | miR-100 | Tumor tissues | ↑OS | [119] |
miR-29c | [120] | |||
miR-181d, -195-5p | [80] | |||
miR-128 | [121] | |||
Let-7b, miR-205 | ↑RFS, OS | [122] | ||
miR-342-5p | [123] | |||
miR-497 | ↓TNM, LNM | [124] | ||
miR-133a | ↑RFS | [125] | ||
miR-30 family | ↑ OS, RFS, DFS ↓Metastasis |
[111–113] | ||
miR-206 | ↑OS ↓TNM, LNM | [126] | ||
miR-601 | ↓Metastasis ↑MFS | [102] | ||
miR-124 | ↑OS ↓TNM, LNM | [127] | ||
miR-138 | ↓TNM, LNM | [103] | ||
miR-190b | ↑MFS, OS | [75] | ||
miR-200b | ↓LNM | [128] | ||
miR-29b | ↑DFS, OS | [129] | ||
miR-27a | [130] | |||
miR-374b-5p, -218-5p, -126-3p |
TNBC tissues | ↑DFS, OS | [131] | |
miR-155 -493 | ↑OS | [117] | ||
let-7c, miR-99a, -125b | Luminal A BC tissues | ↑OS | [116] | |
miRNAs associated with negative outcome | miR-21 | Tumor tissues | ↑Grade, TNM, LNM, metastasis ↓DFS, RFS, OS |
[107, 108] |
miR-210 | ↓OS, RFS, DFS, MFS ↑Grade | [109] | ||
miR-23a | ↓RFS | [66] | ||
miR-423 | ↑Metastasis | [132] | ||
miR-9 | ↑Grade, metastasis, LR | [87] | ||
miR-187 | ↓DSS, RFS | [133] | ||
miR-155 | ↑TNM, grade, LNM ↓OS | [134] | ||
miR-221/222 | ↓MFS | [135] | ||
miR-421, -486, -503, -720, -1303 | ↓MFS | [136] | ||
miR-375 | ↑LR | [137] | ||
miR-548 family | ↑LNM ↓MFS | [95] | ||
miR-146a-5p | ↓OS | [80] | ||
miR-27b-3p | TNBC tissues | ↑Metastasis ↓DSS | [138] | |
miR-93 | ↑LNM, TNM, grade, Ki-67 | [139] | ||
miR-21, -210, -221 | ↓DFS, OS | [140] | ||
miR-34b | [141] | |||
miR-18b, -103, -107, -652 | TNBC patients serum | ↓OS, RFS. | [142] | |
miR-200b | BC patients plasma | ↓PFS, OS | [86] | |
miR-202 | BC patients serum | ↓OS | [143] | |
miR-10b-5p | ↑TNM, grade, LNM | [144] | ||
miR-122 | ↓MFS, RFS | [78] | ||
miR-10b, -34a, -155 | ↑Metastasis | [145] |
↑Incresead; ↓ Decreased
RFS relapse-free survival, TNM TNM classification of malignant tumours, MFS metastasis-free survival, LR local recurrence, DSS disease-specific survival