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. Author manuscript; available in PMC: 2016 Oct 6.
Published in final edited form as: Cell Metab. 2015 Aug 13;22(4):646–657. doi: 10.1016/j.cmet.2015.07.011

Figure 5. Satiety action of 5-HTR agonist requires AgRP neurons integrity on chow diet but not palatable diet.

Figure 5

(A, B, C and D) 4-h caloric response to fast (A and C) and 2-h cumulative food intake (B, D) of control (black, grey) and AgRP-ablated mice (red, rose) fed a chow diet, injected IP, 45 min prior refeeding, with NaCl (black, red) or the 5-HT1BR agonist CP (A and C, grey, rose) or the 5-HT2CR agonist WAY (B and D, grey, rose). (E and F) 2-h caloric intake (E) and cumulative (F) after an injection (IP) of NaCl (black) ghrelin (white box) associated with CP (blue box) and CP alone (grey box). (G, H, I, and J) 4-h response (G and I) and cumulative (H and J) caloric intake to fast in AgRP-ablated (orange, brown) or control (blue, navy blue) mice fed HFHS diet, injected 45 min prior to refeeding with NaCl (blue, orange), CP (G and H navy blue, brown) or WAY (I and J. navy blue, brown). n=6–10 mice in each group. a, b and c, differ significantly (P<0.05). Data are expressed as mean ± SEM.

HHS Vulnerability Disclosure