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Sickle mice exhibit evidence of diastolic dysfunction by tissue Doppler imaging (TDI). Six- to 9-mo-old age- and gender-matched sickle (Berk-SS) and WT mice underwent cardiac echocardiography with TDI. Select panels are shown that depict (A) mitral valve early filling (MV E), (B) mitral valve late filling (MV A), and (C) ratio of transmitral E and e′ (MV IVS E/e′). Data shown as mean ± SEM, n = 8–14 mice in WT and 5–10 mice in Berk-SS; Mann–Whitney U test; *P ≤ 0.05; **P ≤ 0.01.
