Fig. 3.

Sickle mice exhibit LV hypertrophy and dilation with preserved systolic function but increased myocardial fibrosis by CMR. Six- to 9-mo-old age- and gender-matched sickle (Berk-SS) and WT mice underwent CMR. Panels depict (A) left and right end-diastolic volumes (LVEDV and RVEDV, respectively); (B) LV ejection fraction (LVEF) and stroke volume (SV); (C) LVM; and (D) myocardial extracellular volume (ECV%) measured by contrast-enhanced T1 mapping. Data shown as mean ± SEM n= 3–7 mice in WT and 7–9 mice in Berk-SS; Mann–Whitney U test; ns, P > 0.05; **P ≤ 0.01; ***P ≤ 0.001.