Fig. 7.

(A) Gene Ontology pathways that are differentially regulated between WT and Berk-SS mouse myocardium (n = 3 WT and 3 in Berk-SS), following a sickle myocardial transcriptome (with associated P values) compared with WT myocardial transcriptome; arrows indicate up- or down-regulated pathways in the sickle myocardium. (B) Immunohistochemistry staining of CTGF in mouse myocardium. Compared with age- and gender-matched WT myocardium (a, c, e, g), an 8-mo-old Berk-SS mouse shows increased overall background expression (b, d, f, h) with several areas of pronounced focal staining (perivascular regions and areas of myocyte loss).