TABLE 1.
Biometric and metabolic data assessed by CLAMS of NaPi2a−/− mice on LPD and HPD for 10 wk and of WT mice on RC and LPD for 2 wk
| Parameter |
NaPi2a−/− diet for 10 wk |
WT diet for 2 wk |
|||||
|---|---|---|---|---|---|---|---|
| WT on RC | LPD | HPD | P (LPD vs. HPD) | RC | LPD | P (RC vs. LPD) | |
| Body weight (g) | 27.4 ± 0.5 | 25.7 ± 0.9 | 28.8 ± 1.3 | 28.1 ± 0.9 | 26.1 ± 0.3 | ||
| Muscle mass (g) | 20.5 ± 0.5 | 17.4 ± 0.5 | 19.1 ± 0.6 | 0.05 | 21.4 ± 0.3 | 20.3 ± 0.2 | 0.03 |
| Fat mass (g) | 1.5 ± 0.2 | 2.9 ± 0.2 | 4.3 ± 0.7 | 3.0 ± 0.3 | 2.1 ± 0.3 | ||
| Muscle mass (%) | 74.9 ± 0.7 | 67.8 ± 0.5 | 67.0 ± 1.2 | 76.4 ± 2.0 | 77.6 ± 0.9 | ||
| Fat mass (%) | 5.5 ± 0.8 | 11.0 ± 0.7 | 14.0 ± 1.7 | 10.6 ± 0.8 | 8.1 ± 1.0 | ||
| VO2 (ml/kg/h) | 2972.4 ± 38.0 | 3439.4 ± 93.6 | 3350.0 ± 136.8 | 3300.9 ± 27.7 | 3422.2 ± 25.0 | <0.01 | |
| VCO2 (ml/kg/h) | 2719.7 ± 38.0 | 3145.5 ± 79.3 | 3112.7 ± 149.0 | 3166.9 ± 24.8 | 3408.5 ± 27.7 | <0.01 | |
| RER | 0.91 ± 0.01 | 0.91 ± 0.01 | 0.92 ± 0.01 | 0.96 ± 0.01 | 0.99 ± 0.01 | <0.01 | |
| Energy expenditure (Kcal/kg/h) | 14.6 ± 0.2 | 17.0 ± 0.4 | 16.2 ± 0.5 | 16.5 ± 0.1 | 17.2 ± 0.1 | <0.01 | |
| Energy intake (Kcal/kg/h) | 17.5 ± 0.5 | 23.2 ± 2.4 | 23.2 ± 1.2 | 26.7 ± 1.5 | 36.6 ± 2.5 | <0.01 | |
| Activity index (counts/min) | 158.5 ± 19.4 | 78.1 ± 8.9 | 109.7 ± 7.8 | 0.01 | 52.5 ± 2.4 | 44.1 ± 1.5 | <0.05 |
All data are means ± sem; n = 8–10 in each group. P values are indicated when significant by double-sided Student’s t test. RC, regular chow (0.7% Pi, 1.0% Ca). See Fig. 1 for composition of LPD and HPD.