TABLE 1.
Genotype distribution (no. of participants) among reproductive states and choline intake groups
| Choline intake and variant alleles (n) | ||||||
|---|---|---|---|---|---|---|
| Genotype and reproductive state | 480 mg/d |
930 mg/d |
||||
| 0 | 1 | 2 | 0 | 1 | 2 | |
| MTHFR rs1801133 | ||||||
| Lactating | 4 | 7 | 1 | 5 | 6 | 1 |
| NP | 3 | 4 | 3 | 6 | 5 | 0 |
| Pregnant | 5 | 8 | 0 | 6 | 5 | 2 |
| MTR rs1805087 | ||||||
| Lactating | 8 | 4 | 0 | 8 | 4 | 0 |
| NP | 6 | 3 | 1 | 8 | 3 | 0 |
| Pregnant | 10 | 3 | 0 | 8 | 5 | 0 |
| MTHFD1 rs2236225 | ||||||
| Lactating | 4 | 7 | 1 | 1 | 8 | 3 |
| NP | 1 | 7 | 2 | 2 | 8 | 1 |
| Pregnant | 6 | 6 | 1 | 4 | 5 | 4 |
| MTRR rs1801394 | ||||||
| Lactating | 6 | 3 | 3 | 3 | 7 | 2 |
| NP | 2 | 6 | 2 | 5 | 3 | 3 |
| Pregnant | 2 | 9 | 2 | 2 | 7 | 4 |
Because of the relatively low prevalence of the variant allele, heterozygous and homozygous variant individuals were combined to examine the effect of variant allele presence on metabolic outcomes.