TABLE 10.
MTHFD1 rs2236225 genotype alters plasma and breast-milk choline metabolite partitioning among lactating women
| MTHFD1 rs2236225 group | 480 mg/d choline |
930 mg/d choline |
||||
|---|---|---|---|---|---|---|
| Nonvariant | Variant | In CI? | Nonvariant | Variant | In CI? | |
| Plasma | ||||||
| PC-d3/PC-d9 | 0.29 (0.26–0.32) | 0.23 (0.21–0.25) | No | 0.18a | 0.33 (0.31–0.36) | No |
| Choline-d3/choline-d9 | 0.32 (0.27–0.36) | 0.24 (0.22–0.26) | No | 0.18a | 0.34 (0.30–0.36) | ɸ |
| Betaine-d3/betaine-d9 | 0.25 (0.20–0.30) | 0.18 (0.17–0.20) | No | 0.09a | 0.23 (0.20–0.25) | No |
| Breast milk | ||||||
| PC-d3/PC-d9 | 0.23 (0.18–0.29) | 0.18 (0.17–0.19) | Yesb | 0.13a | 0.23 (0.21–0.26) | No |
| Choline-d3/choline-d9 | 0.26 (0.24–0.28) | 0.22 (0.20–0.25) | Yes* | 0.14a | 0.29 (0.26–0.34) | No |
| Betaine-d3/betaine-d9 | 0.80 (0.63–0.97) | 0.51 (0.37–0.66) | Yes* | 0.33a | 0.71 (0.61–0.80) | No |
Values are group means with 95% CIs in parentheses. Although nonoverlapping CIs indicate a significant difference, overlapping CIs do not necessarily exclude a significant difference. In cases where CIs were overlapping, a Student’s t test was performed using the Welch–Satterthwaite equation to calculate degrees of freedom.
a
Not available, single participant.
b
Student’s t test failed to reject the null hypothesis.
*
P ≤ 0.05 by Student’s t test.