TABLE 5.

Comparison of choline → betaine and betaine → methionine turnover between choline intake groups among MTR rs1805087 variant and nonvariant women

MTR rs1805087 group	480 mg/d choline	930 mg/d choline	P
Choline → betaine
NP WT	33 ± 6	50 ± 5	>0.99
NP variant	23 ± 7	94 ± 9	<0.001***
Betaine → methionine
WT	1.5 ± 0.06	1.8 ± 0.06	<0.001***
Variant	1.7 ± 0.08	1.6 ± 0.08	0.6

Values are least-squares means ± se in millimolar product per study period; symbols denote significance at the indicated α-cutoff. ***P ≤ 0.001.