TABLE 8.
MTHFD1 rs2236225 genotype alters plasma choline metabolite partitioning
| MTHFD1 rs2236225 group | 480 mg/d choline |
930 mg/d choline |
||||
|---|---|---|---|---|---|---|
| Nonvariant | Variant | P | Nonvariant | Variant | P | |
| Betaine-d9/PC-d9 | ||||||
| 3-Way interaction; P = 0.01** | ||||||
| Lactating | 0.81 ± 0.05 | 0.79 ± 0.03 | >0.99 | 0.93a | 0.96 ± 0.03 | in CI |
| NP | 1.07a | 0.73 ± 0.03 | ɸ | 0.91 ± 0.07 | 0.96 ± 0.03 | >0.99 |
| Pregnant | 0.69 ± 0.04 | 0.67 ± 0.04 | >0.99 | 0.83 ± 0.05 | 0.74 ± 0.03 | >0.99 |
| PC-d3 + 6/PC-d9 | ||||||
| 3-Way interaction; P = 0.0001*** | ||||||
| Lactating | 0.31 ± 0.02 | 0.24 ± 0.02 | 0.2 | 0.19a | 0.36 ± 0.01 | ɸ |
| NP | 0.33a | 0.28 ± 0.02 | ɸ | 0.32 ± 0.03 | 0.38 ± 0.02 | >0.99 |
| Pregnant | 0.24 ± 0.02 | 0.26 ± 0.02 | >0.99 | 0.36 ± 0.02 | 0.31 ± 0.02 | >0.99 |
Values are ratios as least-squares means ± se. ɸ, the least-squares mean of the representative individual falls outside of the 95% CI of the comparing group. P values represent the highest order interaction or main effect; symbols denote significance at the indicated α-cutoff.
a
Not available, single participant.
**P ≤ 0.01, ***P ≤ 0.001.