Figure 3.

Differences in expression signatures between the twins. A) Heat map of the z scores for the signature Δ expression levels. Left column: signature Δ z score for the non-ALS PBMC sampled on October 15, 2013; right column: signature Δ z score for the ALS PBMCs sampled on July 19, 2013. Red: higher signature expression level vs. the mean Δ. Blue: lower signature expression level vs. the mean Δ. Among the 13 expression signatures, the dendritic cell signature z score reveals a significant difference from the matrix mean. B) A volcano plot of the 15,152 normalized gene count. Differences between the twins in gene expression are shown as log₂ on the horizontal axis. The significance of differentially expressed genes is shown on the vertical axis, with a minimum Bonferroni corrected −log₁₀, P = 6.18.