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. 2016 Jul 1;30(10):3461–3473. doi: 10.1096/fj.201600259RR

Figure 4.

Figure 4.

Cytokine concentrations in the twins. Cytokines in the 2014 twin samples. A) Serum cytokines: only picogram per milliliter concentrations of cytokine with equal concentrations of IL-6 in both twins. B) PBMC supernatant cytokines: up to 10 ng/ml concentrations of IL-6 in PBMC supernatants of the ALS twin in the absence or presence of SOD-1 or tocilizumab with matched or with mismatched serum; substantial IL-6 concentrations in the PBMC supernatants of the non-ALS twin were present only with SOD-1 stimulation; other cytokines, GM-CSF, IL10, IL-1β and TNF-α showed similar differences. C) Macrophage supernatant cytokines: up to 2 ng/ml of IL-6 in the supernatants of the ALS twin’s macrophages, with or without SOD-1 or tocilizumab stimulation with matched or with mismatched serum; no IL-6 produced by non-ALS macrophages; and TNF-α, IL-10, and IL-1β were produced in negligible amounts.