Table 2.
QTcF by cohort and time
| Time (hours) | Placebo | 3 mg | 6 mg | 9 mg | 12 mg | 15 mg |
|---|---|---|---|---|---|---|
| 0 | 399.5 (356, 418) | 396 (374, 414) | 411.5 (387, 425) | 401.5 (373, 423) | 389 (376, 422) | 390 (371, 431) |
| 1.5 | 399.5 (360, 420) | 396.5 (375, 413) | 407 (382, 430) | 392.5 (373, 421) | 391.5 (374, 420) | 394 (371, 431) |
| 2 | 396 (365, 419) | 390 (375, 414) | 404.5 (387, 426) | 392.5 (376, 427) | 388.5 (377, 426) | 394 (376, 426) |
| 3 | 400 (368, 416) | 389 (375, 409) | 403.5 (385, 424) | 390 (377, 424) | 393 (373, 419) | 393 (366, 427) |
| 4 | 401 (367, 422) | 397.5 (376, 407) | 409.5 (390, 424) | 394 (375, 417) | 392 (375, 431) | 389 (366, 427) |
| 8 | 395 (354, 410) | 388.5 (372, 413) | 401.5 (379, 413) | 389 (356, 417) | 388 (363, 400) | 387 (371, 414) |
Notes: Median (min, max) is presented; QTcF, corrected QT by Fridericia correction formula.