Table 3.
ΔQTcF by cohort and time
| Time (hours) | Placebo | 3 mg | 6 mg | 9 mg | 12 mg | 15 mg |
|---|---|---|---|---|---|---|
| 0 | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| 1.5 | −1 (−7.67, 3.33) | 3.7 (−16.33, 4) | −0.7 (−8.33, 5.33) | −3 (−11.33, 1.33) | −0.3 (−9.67, 5) | 3.3 (−3.33, 8.67) |
| 2 | −1.7 −12.67, 7.33) | 0.8 (−14.33, 4.33) | −1.3 (−9.67, 7) | −3.2 (−7.67, 1.67) | 0.3 (−7.33, 4.67) | 3.3 (−1.33, 6) |
| 3 | 1.3 (−10, 9) | −1.7 (−9.33, 3) | −4 (−10, 3) | −5.2 (−10.33, 5.33) | −0.5 (−6.67, 6) | 1.2 (−2, 6.33) |
| 4 | 0.7 (−13, 8) | −1.3 (−11.33, 5.33) | −0.7 (−6.33, 3) | −2.8 (−10, −1.33) | −0.5 (−7, 8.67) | −1.3 (−6.67, 3) |
| 8 | −6.5 (−19, 4.67) | −6.5 (−15.33, 4.33) | −7.2 (−19.67, −2) | −12.3 (−26, −2) | −5.3 (−21.67, 6) | −5 (−14.67, 16.67) |
Note: Median (min, max) is presented.
Abbreviations: QTcF, corrected QT by Fridericia correction formula; ΔQTcF, change-from-baseline of QTcF.