Table 2.
Fatty acid derivatives in tumor tissue.
| Eicosanoid (ng/mg protein) for M-Wnt for Wnt-1 |
Control Diet n = 9 n = 9 |
Control + EPA+DHA n = 5 n = 5 |
DIO n = 9 n = 8 |
DIO + EPA+DHA n = 9 n = 9 |
|---|---|---|---|---|
| M-Wnt 6ketoPGF1α | 12.2 ± 4.7 | 3.9 ± 1.7a | 12.7 ± 3.3b | 22.9 ± 8.9b |
|
| ||||
| Wnt-1 6ketoPGF1α | 3.5 ± 1.3 | 3.2 ± 1.8 | 9.4 ± 6.1 | 4.2 ± 2.3 |
|
| ||||
| M-Wnt TXB2 | 44.6 ± 12.7 | 13.5 ± 5.3 | 128.2 ± 45.2 | 80.4 ± 23.1 |
|
| ||||
| Wnt-1 TXB2 | 3.9 ± 1.4 | 1.2 ± 0.4 | 7.9 ± 4.8 | 3.2 ± 1.4 |
|
| ||||
| M-Wnt PGF2α | 3.3 ± 0.9a | 1.1 ± 0.7a | 8.8 ± 3.3 | 7.6 ± 1.8b |
|
| ||||
| Wnt-1 PGF2α | 1.9 ± 0.8 | 0.23 ± 0.06 | 3.1 ± 1.9 | 1.7 ± 0.8 |
|
| ||||
| M-Wnt PGE2 | 9.0 ± 2.8 | 4.4 ± 1.0a | 10.0 ± 2.8 | 13.6 ± 1.6b |
|
| ||||
| Wnt-1 PGE2 | 8.6 ± 3.7 | 2.3 ± 0.9 | 18.3 ± 9.4 | 5.4 ± 2.3 |
|
| ||||
| M-Wnt PGE3 | 0.11 ± 0.04 | 0.085 ± 0.037a | 0.071 ± 0.017a | 0.25 ± 0.08b |
|
| ||||
| Wnt-1 PGE3 | 0.08 ± 0.03 | 0.03 ± 0.01 | 0.14 ± 0.07 | 0.15 ± 0.09 |
|
| ||||
| M-Wnt PGD2 | 144.2 ± 51.1 | 99.8 ± 42.4a | 385.1 ± 62.4b | 220.6 ± 67.3 |
|
| ||||
| Wnt-1 PGD2 | 5.7 ± 2.3 | 1.4 ± 0.6 | 8.9 ± 4.4 | 4.3 ± 1.6 |
|
| ||||
| M-Wnt 13HODE | 40.3 ± 10.3 | 12.4 ± 6.7a | 47.9 ± 17.6 | 99.0 ± 30.2b |
|
| ||||
| Wnt-1 13HODE | 2.6 ± 1.1a | 2.1 ± 1.7a | 12.8 ± 5.3 | 11.0 ± 2.6b |
|
| ||||
| M-Wnt 15HETE | 9.5 ± 2.8 | 3.2 ± 0.8a | 28.4 ± 9.5b | 17.5 ± 4.9b |
|
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| Wnt-1 15HETE | 1.3± 0.5 | 0.61 ± 0.17a | 4.1 ± 1.9b | 2.1 ± 0.6 |
|
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| M-Wnt 12HETE | 28.6 ± 9.8 | 12.2 ± 3.8a | 31.5 ± 9.8 | 32.9 ± 8.1b |
|
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| Wnt-1 12HETE | 21.9 ± 6.8 | 5.6 ± 1.5a | 39.3 ± 17.6 | 20.1 ± 4.8b |
|
| ||||
| M-Wnt 5HETE | 3.2 ± 0.7a | 2.1 ± 0.5a | 28.9 ± 11.9b | 8.9 ± 2.6b |
|
| ||||
| Wnt-1 5HETE | 0.65 ± 0.15 | 0.60 ± 0.19 | 1.6 ± 0.5 | 0.87 ± 0.19 |
|
| ||||
| M-Wnt 18HEPE | 0.004 ± 0.004a | 0.038 ± 0.016b | 0.037 ± 0.012b | 0.053 ± 0.030 |
|
| ||||
| Wnt-1 18HEPE | NA | NA | NA | NA |
6-ketoPGF1α, 6-keto prostaglandin F1α; TXB2, thromboxane B2; PGE3, prostaglandin E3; PGF2α, prostaglandin F2α; PGE2, prostaglandin E2; PGD2, prostaglandin D2; 13HODE, 13-hydroxyoctadecadienoic acid; 15HETE, 15-hydroxyeicosatetraenoic acid; 12HETE, 12-hydroxyeicosatetraenoic acid; 5HETE, 5-hydroxyeicosatetraenoic acid; 18HEPE, 18-hydroxyeicosapentaenoic acid. Statistically significant (P≤0.05) differences are indicated by different letters, e.g., a group designated with is a different than a group designated with b; but two groups with a are not different.