Table 3. Cumulative effects of IGFBP-3 rs2854744, DISI, and BMI on breast cancer risk.
| NO. a | Total | Premenopausal | Postmenopausal | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Cases (%) | Controls (%) | OR (95%CI)b | Cases (%) | Controls (%) | OR (95%CI)c | Cases (%) | Controls (%) | OR (95%CI)d | |
| 0 | 28(10.1) | 36(13.0) | 1.00 | 18(12.6) | 20(10.7) | 1.00 | 10(7.5) | 16(17.8) | 1.00 |
| 1 | 101(36.5) | 140(50.5) | 0.93(0.53–1.62) | 57(39.9) | 91(48.7) | 0.70(0.34–1.43) | 44(32.8) | 49(54.4) | 1.44(0.59–3.49) |
| 2 | 116(41.9) | 86(31.0) | 1.73(0.98–3.06) | 54(37.8) | 66(35.3) | 0.91(0.44–1.89) | 62(46.3) | 20(22.2) | 4.96(1.94–12.66) |
| 3 | 32(11.6) | 15(5.4) | 2.74(1.25–6.03) | 14(9.8) | 10(5.3) | 1.56(0.56–4.36) | 18(13.4) | 5(5.6) | 5.76(1.62–20.45) |
| P trend | 0.015 | 0.489 | <0.001 | ||||||
a: The number of exposure factors, defined as theIGFBP-3 rs2854744 AA genotype, DISI <9.85 mg/day, and BMI ≥24 kg/m2
b: adjusted for education, income, age at first pregnancy, parity, breast feeding, and energy-adjusted protein, fat and dietary fiber intake
c: adjusted for education, income, age at first pregnancy, parity, breast feeding, and energy-adjusted protein, fat, carbohydrate and dietary fiber intake
d: adjusted for education, income, age at first pregnancy, parity, breast feeding, and contraceptive use