Table 1.
Characteristics of study patients
| Quetiapine (n=21) |
Aripiprazole (n=12) |
P-value | |
|---|---|---|---|
| Age, mean (SD) | 72.1 (5.3) | 71.0 (4.6) | 0.53** |
| Mean number of depressive episodes (SD) | 1.9 (1.2) | 1.83 (1.1) | 0.77** |
| Female (%) | 11 (52.4) | 8 (66.6) | 0.48* |
| Mean education, years (SD) | 6.3 (4.3) | 6.83 (4.5) | 0.73** |
| Psychotic features (%) | 5 (23.8) | 4 (33.3) | 0.42* |
| Having medical illness (%) | 16 (76.2) | 10 (83.3) | 0.49 |
| Hypertension | 11 (52.4) | 5 (41.6) | 0.47 |
| Diabetes | 5 (23.8) | 7 (58.3) | 0.05 |
| Orthopedic | 4 (19.0) | 3 (25) | 0.50* |
| Other | 5 (23.8) | 4 (33.3) | 0.42* |
| Mean dosage, mg (SD) | 85.71 (47.8) | 3.3 (1.2) | |
| Mean number of medications for medical illness (SD) | 2.38 (1.4) | 2.16 (1.2) | 0.64** |
| Dropout ratio at the fourth week (%) | 9 (42.8) | 4 (33.3) | 0.43* |
| Dropout ratio between the fifth and twelfth weeks (%) | 5 (23.8) | 5 (41.7) | 0.24 |
| Number of patients completed 12 weeks (%) | 7 (33.3) | 3 (25) | 0.46* |
| Mean GDS, baseline (SD) | 20.3 (3.0) | 19.91 (2.8) | 0.41** |
| Mean GDS, 4 weeks (SD) | 18.7 (4.8) n=12 |
17.12 (2.5) n=8 |
|
| Mean GDS, 12 weeks (SD) | 19.00 (4.9) n=7 |
14.7 (3.0) n=3 |
|
| Mean MMSE, baseline (SD) | 26.9 (1.1) | 27.1 (1.1) | 0.65** |
| Mean MMSE, 12 weeks (SD) | 27.6 (1.1) | 27.7 (1.2) | 0.75** |
| Number of patients having any adverse event (%) | 13 (61.9) | 5 (41.6) | 0.22 |
| Type of antidepressants combined with AAP | |||
| SSRIs (%) | 8 (38.1) | 3 (25) | 0.35* |
| SNRI (%) | 6 (28.6) | 4 (33.3) | 0.53* |
| Combination SSRI and SNRI (%) | 7 (33.3) | 5 (41.7) | 0.45 |
Notes:
*
Fisher’s exact test,
**
Student’s t-test.
Abbreviations: AAP, atypical antipsychotic; GDS, Geriatric Depression Scale; MMSE, Mini-Mental State Examination; SD, standard deviation; SSRI, selective serotonin reuptake inhibitor; SNRI, serotonin/norepinephrine reuptake inhibitor.