Fig 3. Overlap in onion-induced differentially expressed genes detected in human Caco-2 model, rat slices and pig SISP.

A) Of 9,140 genes that were expressed in all three models, the overlap in onion-induced differential gene expression was determined (raw/unadjusted p-value<0.05 and FC > 1.5 or < 0.66). Expression of overlapping genes changed in the same direction (up- or downregulated). B) Overlap in differentially expressed genes (raw/unadjusted p-value<0.05) between human Caco-2 and pig SISP. C) Overlap in differentially expressed genes (raw/unadjusted p-value<0.05) between human Caco-2 and rat slices. Dark red and green indicates differential gene expression with fold changes >1.5 and <0.667, light red en green indicates fold changes >1.2 and <0.833. N/A; did not meet the 'flooring' criteria (low/no expression), so excluded from further analyses. * no homologues found in pig, only related genes (Sulfiredoxin-1-like).