. 2016 Sep 15;11(9):e0160560. doi: 10.1371/journal.pone.0160560

Table 2. Risk of AOM recurrences during the first four years of life by treatment of first episode.

	Antibiotic treatment for first AOM episode
	Crude rate ratio (95% CI)	Adjusted rate ratio^a (95% CI)
Total number of AOM recurrences	0.87 (0.73–1.04)	0.94 (0.78–1.13)
	Crude risk ratio (95% CI)	Adjusted risk ratio^a (95% CI)
Recurrent AOM	0.77 (0.55–1.07)	0.79 (0.57–1.11)

In all analysis follow-up duration was used as the offset variable.

^a Adjusted for confounders: gender, season of birth, parental education level, duration of exclusive breastfeeding, number of older siblings, household-smoking, daycare attendance, age of first AOM episode and number of oral antibiotics prior to the first AOM episode (irrespective of indication).

Abbreviations: AOM, acute otitis media. CI, confidence interval.