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. 2016 Sep 15;11(9):e0162586. doi: 10.1371/journal.pone.0162586

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© 2016 Budzinska et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 6 — HCC progression is presented here as multiple waves of driver sweeps within hepatocyte subclones. The equilibrium between DPM accumulation and negative selection on the hepatocyte subclones are shown in the top row. A schematic model of the liver (with each circle representing a hepatocyte and the colour gradient representing the DPM load within each hepatocyte) is shown in the centre row. The average DPM load for the tissue is depicted in the bottom row.