. Author manuscript; available in PMC: 2017 Aug 5.

Published in final edited form as: J Proteome Res. 2016 Jul 20;15(8):2802–2811. doi: 10.1021/acs.jproteome.6b00370

Table 2.

Endogenous metabolites significantly associated with IV busulfan clearance by univariate analysis

Metabolite	Function^a	Direction^b	P-value	q-value^c
Glycine	Amino acid; involved in biosynthesis of proteins, including glutathione, involved the metabolism of busulfan, as well as purines, heme, bile salts, and creatine; inhibitory neurotrasmitter	+	0.0006	0.08
N-Acetylglycine	Acetylated glycine; important for synthesis, stability and localization of proteins	+	0.002	0.09
2-Hydroxyisovaleric Acid	Fatty acid; derived from metabolism of valine, leucine and isoleucine; may originate from ketogenesis	−	0.002	0.09
Creatine	Involved in energy production, primarily in muscle; produced from glycine and arginine	+	0.006	0.23
Serine	Amino acid; involved in production of purines and pyrimidines; inhibitory neurotransmitter	+	0.03	0.80
Tyrosine	Amino acid; biosynthesis of proteins; essential component of neurotransmitters; receptor kinases involved in immune signaling	−	0.03	0.80

Information pertaining to function is derived from Kyoto Encyclopedia of Genes and Genomes, Human Metabolome Database or PubChem unless otherwise noted

Indicates whether the metabolite was positively or negatively associated with IV busulfan clearance

False discovery rate (Benjamini-Hochberg)