FIGURE 4:

Efficiency of pushing forces with pivoting and gliding allowed. (A–C) Simulations in which one parameter was geometrically varied: MT rigidity, from 1 to 300 pN/μm²; MT unloaded catastrophe rate, from 0.01 to 0.06 s⁻¹; and number of MTs in the aster, from 15 to 350. Left, two exemplary simulations (400 s) obtained by varying one parameter in each case. Middle, trajectories of centrosomes obtained by varying one parameter, displayed along an arc, with increasing values from left to right. For each trajectory, time is indicated by the color, from blue (0 s) to red (400 s). The center of each disk is marked with a black dot. Right, centrosome positioning as a function of various parameters, measured by the distance to the cell center. The dotted lines represent the initial centrosome–center distance (half of the confinement radius).