Table 1.
Cytoplasmic Dicer staining and clinicopathologic characteristics of 262 cases of primary melanomas
| Cytoplasmic Dicer staining
|
Total | p value* | |||
|---|---|---|---|---|---|
| Negative | Weak | Strong | |||
| Age | |||||
| ≤62 | 15 (11.2%) | 31 (23.1%) | 88 (65.7%) | 134 | 0.702 |
| >62 | 15 (11.7%) | 35 (27.3%) | 78 (61.0%) | 128 | |
| Sex | |||||
| Male | 23 (16.7%) | 32 (23.2%) | 83 (60.1%) | 138 | 0.009 |
| Female | 6 (4.8%) | 35 (28.2%) | 83 (67.0%) | 124 | |
| Tumor thickness (mm) | |||||
| ≤2 mm | 12 (8.2%) | 34 (23.1%) | 101 (68.7%) | 147 | 0.073 |
| >2mm | 18 (15.7%) | 32 (27.8%) | 65 (56.5%) | 115 | |
| Ulceration | |||||
| Present | 8 (14.8%) | 14 (25.9%) | 32 (59.3%) | 54 | 0.648 |
| Absent | 22 (10.6%) | 52 (25.0%) | 134 (64.4%) | 208 | |
| Lymphocytic response | |||||
| Present | 12 (12.8%) | 15 (15.9%) | 67 (71.3%) | 94 | 0.036 |
| Absent | 18 (10.7%) | 51 (30.4%) | 99 (58.9%) | 168 | |
| Tumor subtype | |||||
| Lentigo maligna | 10 (21.3%) | 9 (19.1%) | 28 (59.6%) | 47 | 0.256 |
| Superficial spreading | 8 (8.8%) | 24 (26.4%) | 59 (64.8%) | 91 | |
| Nodular | 5 (10.9%) | 9 (19.6%) | 32 (69.5%) | 46 | |
| Other† | 7 (9.0%) | 24 (30.8%) | 47 (60.2%) | 78 | |
| Site‡ | |||||
| Sun-exposed | 13 (13.8%) | 22 (23.4%) | 59 (62.8%) | 94 | 0.632 |
| Sun-protected | 17 (10.1%) | 44 (26.2%) | 107 (63.7%) | 168 | |
*
χ2 test.
†
Other: unspecified subtype.
‡
Sun-protected sites: trunk, arm, leg and feet; Sun-exposed sites: head and neck.