Table 3.

Clinical change of GAF and PANSS for patients of the three clusters from disease onset to endpoint

Clinical variable	Cluster	Change over time (adjusted mean)	SE	F	Global p value	Post hoc analyses
						GI versus SI	GI versus NN	SI versus NN
GAF-S	GI	15.0	2.2
	SI	25.1	1.6	9.23	0.0002	0.0004	<0.0001	0.43 NS
	NN	26.6	1.5
GAF-F	GI	12.9	2.0
	SI	18.3	1.5	4.60	0.013	0.035	0.003	0.22 NS
	NN	20.6	1.4
PANSS-T	GI	−2.7	0.3
	SI	−3.9	0.2	5.68	0.005	0.003	0.002	0.9 NS
	NN	−3.9	0.2

In the table, GI stands for cluster of generally impaired patients, SI for cluster of selectively impaired patients and NN for cluster of near-normal functioning patients. The three clusters of patients were compared on the change in scores from disease onset to endpoint (mean change on GAF symptom, GAF functioning and PANSS-T) by means of ANCOVA. For each clinical variable, age, gender and scores at onset on each clinical variable were entered as covariables in the analysis. The clusters were found significantly different in terms of their improvement on disease severity (GAF symptom), functioning (GAF function) and symptoms (PANSS-T). Post hoc tests of between-group comparisons show that patients of the two cognitively impaired clusters, generally impaired and selectively impaired, displayed different patterns of improvement over time. The selectively impaired patients had significantly better evolutions of their GAF symptom (p = 0.0004), GAF functioning (p = 0.035) and PANSS-T (p = 0.003) than the generally impaired cluster. The bold italic emphasizes the post hoc comparison of the generally impaired cluster (GI) versus the selectively impaired cluster (SI)

Bold values indicate statistical significant