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. 2016 Sep 16;7:314. doi: 10.3389/fphar.2016.00314

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Copyright © 2016 Giacomazzi, Degan, Calabria, Meneguzzi and Minuz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In vitro collagen-induced platelet microparticle generation and effects of antiplatelet agents. (A) PMP generation induced by collagen type I at high (10 μg/mL) and low (1.5 μg/mL) concentration in freshly isolated PRP under low shear stress conditions; (B,C) Effects of ASA at high (100 μmol/L) and low (10 μmol/L) concentration on platelet microvesiculation triggered by collagen type I (10 and 1.5 μg/mL). (D,E,F) Effects of SQ 29,548 (20 μmol/L), apyrase (10 U/mL) and PSB-0739 (500 nmol/L) on in vitro PMPs shedding induced by collagen type I (10 and 1.5 μg/mL). ^∗P < 0.05; ^∗∗P < 0.01; ^∗∗∗P < 0.001.