Figure 3.

Alterations in aorta contractility of Tg APP mice. Tg APP aortae showed increased phenylephrine (A) and U46619-induced (B) contraction compared to aortae from wt mice. Vessels were precontracted by 123.5 mM K⁺ and washed before other treatment addition. Aβ (1 μM) incubation increased U46619 (0.03 μM) contraction (C) and decreased ACh (10 μM) relaxation (D) in wt aortae, but not in Tg APP aortae. Preconstriction levels were similar for all the vessels (approximately 5.44 mN). Results are mean ± SEM of n = 7 mice and are expressed as percentage of 123.5 mM K⁺-induced contraction, considered 100%. ^*p < 0.05 (Kruskal-Wallis, followed by Dunn's test).