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Cannabinoid agonists induce dose-dependent vasodilation. Cannabinoid vasodilation was reduced in Tg APP aortae compared to wt (A,B). Concentration-response curves (1 nM-10 μM) for WIN and JWH were performed in segments preconstricted with U46619 (0.03 μM). Preconstriction levels were similar for all the vessels (approximately 8.9 mN). Results are mean ± SEM of n = 6 mice and are expressed as percentage of U46619-induced contraction. *p < 0.05, **p < 0.01 (two way ANOVA).
