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. 2016 Sep 16;10:422. doi: 10.3389/fnins.2016.00422

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Copyright © 2016 Navarro-Dorado, Villalba, Prieto, Brera, Martín-Moreno, Tejerina and de Ceballos.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Electron micrographs of wild type and Tg APP mice. Representative images are shown for wt (A,C,E) and Tg APP mice aortae (B,D,F). (A,B) toluidine blue micrographs showing similar structure (n = 20 animals/per group). BL: basal lamina, (C,D) endothelial cells show similar appearance (wt n = 4, Tg APP n = 6). (E) smooth muscle cells surrounded by collagen in wt mice aorta, (F) muscle cells are embedded in collagen in Tg APP aorta (wt n = 4, Tg APP n = 6). Scale bars, 50 μm in (A,B); 100 nm in (C–F).