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. 2016 Sep 16;7:361. doi: 10.3389/fimmu.2016.00361

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Copyright © 2016 Jalapothu, Boieri, Crossland, Shah, Butt, Norden, Dressel, Dickinson and Inngjerdingen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miRNA expression signature in skin during aGvHD. (A) Volcano plot showing the relationship between fold change and significance between the two groups. The horizontal dashed line indicates cutoff for significance p < 0.05 (−log10 p-value >1.3) and the vertical lines for fold change ≥1.5/≤−1.5. (B) Heatmap showing unsupervised hierarchical clustering of differentially expressed miRNAs in skin between control (n = 2) and aGvHD (n = 3) animals. Each column represents an individual rat. Relative fold change is indicated by the color scale (red: high; blue: low). (C) qRT-PCR analysis of miR-34b and miR-326 expression in skin of control (n = 6) or aGvHD (n = 6) rats. Samples were normalized to endogenous controls and expression levels reported as log of 2^−ΔΔCt ± SD. Significance was calculated using the Student’s t-test (two-tailed) with Welch’s correction.