Table 1.
Effect of CR on serum metabolites
| Metabolite | % of control serum | P value after pFDR correction |
|---|---|---|
| Glucose | 42.0 | 5.5E−08 |
| Lysine | 47.2 | 2.4E−07 |
| Lactate | 50.8 | 3.1E−07 |
| Alanine | 52.0 | 5.53E−08 |
| Pyruvate | 57.3 | 5.6E−06 |
| Tyrosine | 57.7 | 1.07E−06 |
| Fumarate | 60.4 | 0.008 |
| 2-Oxoglutarate | 61.9 | 0.023 |
| Ornithine | 66.1 | 0.018 |
| Acetoacetate | 842.2 | 4.1E−04 |
| 3-Hydroxybutyrate | 500.2 | 4.1E−04 |
| Urea | 164.8 | 0.004 |
| Acetone | 152.8 | 0.017 |
Values represent the average serum concentration change (as percent change in serum from CR mice relative to control-fed mice) of the identified, statistically significant metabolites (Fig. 4c), based on p values after positive false discovery rate (pFDR) correction <0.05