Table 3.
Liver enzymes and function
| A | Anidulafungin | Micafungin | P |
|---|---|---|---|
| (n = 30) | (n = 33) | ||
| Liver failurea | 9 (30) | 2 (6) | 0.01 |
| Increased serum AST (U/L) after starta | 13 (43) | 12 (36) | 0.58 |
| Increased serum ALT (U/L) after starta | 13 (43) | 10 (30) | 0.29 |
| Serum AST (U/L) at start | 95 (282) | 55 (76) | 0.09 |
| Serum ALT (U/L) at start | 56 (125) | 39 (59) | 0.13 |
| Serum AST (U/L) at stop | 115 (1011) | 52 (108) | 0.17 |
| Serum ALT (U/L) at stop | 75 (312) | 45 (68) | 0.14 |
| Serum AST (U/L) peak | 285 (228) | 116 (181) | 0.11 |
| Serum ALT (U/L) peak | 150 (404) | 70 (126) | 0.15 |
| Serum bilirubin (μmol/L) peak | 71 (192) | 15 (29) | 0.05 |
| Prothrombin Time (sec) peak | 18.3 (15.4) | 17.8 (8.0) | 0.27 |
| B | Anidulafungin | Micafungin | P |
| (n = 21) | (n = 31) | ||
| Increased serum AST (U/L) after starta | 8 (38) | 11 (35) | 0.85 |
| Increased serum ALT (U/L) after starta | 7 (33) | 9 (29) | 0.74 |
| Serum AST (U/L) at start | 61 (98) | 55 (73) | 0.82 |
| Serum ALT (U/L) at start | 43 (75) | 39 (54) | 0.89 |
| Serum AST (U/L) at stop | 44 (141) | 49 (79) | 0.98 |
| Serum ALT (U/L) at stop | 41 (83) | 45 (54) | 0.99 |
| Serum AST (U/L) peak | 129 (267) | 113 (158) | 0.88 |
| Serum ALT (U/L) peak | 69 (209) | 61 (119) | 0.95 |
| Serum bilirubin (μmol/L) peak | 20 (105) | 14 (27) | 0.74 |
| Prothrombin Time (sec) peak | 16.6 (7.5) | 17.8 (5.3) | 0.68 |
Numbers (percentage) aor median (interquartile range). Liver enzymes and function in all patients who were treated with anidulafungin and micafungin (A) and in patients without liver failure (B)
Abbreviations: ALT alanine transaminase, AST aspartate transaminase