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. 2016 Sep 15;17:733. doi: 10.1186/s12864-016-3077-4

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Association of HOT regions with functional elements. a–b Examples of HOT regions (red line) overlapping microRNA a and repetitive elements b. Peaks are observed in cell types consistent with known functions of the microRNAs and repetitive elements (pink line). c Examples of known cell-selective experimentally validated distal, non-promoter cis-regulatory elements. Shown above each set of DNaseI data are schematics displaying HOT regions relative to the genes they control. d Examples of colocalisation of DMV (blue) and UMR (pink) with HOT regions (red) in a cell-type-specific manner. See also Additional file 1: Figure S4 and Additional file 2: Tables S6–S7