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. 2016 Sep 15;17:733. doi: 10.1186/s12864-016-3077-4

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Association of distal HOT regions with super-enhancers a Error bar showing the GSC results between distal HOT regions and super enhancers. Red lines indicate the mean and normalised SD of 10,000 bootstrap samples; blue bar indicates the real statistics. b Distal HOT regions colocalise with super-enhancers in a cell type-specific manner. Cell type-specific super-enhancers (y-axis) are mapped relative to cell-specific distal HOT regions (x-axis) in 14 different cell types. c ChIP-seq binding profiles of super-enhancers, enhancers, and distal HOT regions for the indicated DNaseI and enhancer-relevant markers, including transcription factors, transcriptional cofactors, chromatin regulators, and RNA polymerase II in ESCs. See also Additional file 1: Figure S5