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. 2016 Sep 15;17:733. doi: 10.1186/s12864-016-3077-4

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Epigenetic Regulation of HOT regions upon H1 differentiation. a The chromatin state (presence of H3K4me3 and/or H3K27me3) of HOT regions in various cell types. b Dynamic changes of bivalent HOT regions between H1 and H1-derived cell types. c Box plots showing the levels of H3k4me3 (top), H3k27me3 (middle), and mRNA (bottom) at activated and repressive HOT regions in H1 and H1-derived cells. See also Additional file 2: Tables S10 and S11