Table 3.

Grade 3 to 4 adverse events of interest

AEs	I 2	OR	95 % CI	P value
Anemia	0.0 %	1.02	0.83–1.24	0.883
Thrombocytopenia	39.2 %	1.06	0.74–1.51	0.771
Leucopenia	66.1 %	1.24	0.73–2.10	0.433
Neutropenia	85.8 %	1.33	0.88–2.01	0.179
Febrile neutropenia	67.2 %	1.34	0.68–2.67	0.401
Hypokalemia	38.1 %	1.09	0.81–1.47	0.586
Rash	0.0 %	21.84	6.81–70.02	<0.001*
Hand-foot syndrome	37.6 %	1.75	1.22–2.50	0.002*
Stomatitis	42.8 %	2.08	1.23–3.51	0.006*
Nausea	21.6 %	0.94	0.73–1.21	0.639
Vomit	0.3 %	0.99	0.79–1.25	0.944
Abdominal pain	0.0 %	1.10	0.47–2.57	0.821
Diarrhea	14.1 %	2.40	1.88–3.06	<0.001*
Constipation	0.0 %	0.27	0.08–0.91	0.034*
Decreased appetite	0.0 %	1.13	0.88–1.46	0.342
Fatigue	0.0 %	1.55	1.21–2.00	0.001*
Neuropathy	62.8 %	0.76	0.24–2.41	0.636
Any adverse events	86.8 %	1.53	0.98–2.40	0.062

*P < 0.005, There were statistically significant differences between the two arms