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. 2016 Sep 15;16:736. doi: 10.1186/s12885-016-2771-6

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Enrichment of clinicopathological prognositic features of papillary thryroid cancer within intermediate prognosis patients classified as good and poor prognosis by a Prediction of Microarrays (PAM) model. Intermediate prognosis patients (n = 378) were classified as either good (n = 111) or poor prognosis (n = 195) using the PAM model, which was trained using the gene signature of differential expression between extreme good prognosis (n = 51) and extreme poor prognosis (n = 79) patients. Within the poor prognosis group there was a higher percentage of patients with BRAF mutations, nodal involvement, extra-thyroid extension, and the aggressive Tall cell histological subtype, but a lower percentage of patients with NRAS and HRAS mutations and the well-differentiated follicular histological subtype. *** Chi -squared p-value < 0.001