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. 2016 Sep 16;6:33676. doi: 10.1038/srep33676

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Copyright © 2016, The Author(s)

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(A) HDAC9 mRNA expression was significantly increased in renal tissues from DKD patients (n = 19) when compared with control tissues (n = 50) from NCBI Gene Expression Omnibus database (GEO, Access ID: GSE30122) (P < 0.0001). (B) GSEA was performed with KEGG E-MEXP-3628 dataset. JAK/STAT pathway was with the strongest association with HDAC9-higher expression. (C) HDAC9 protein level and STAT3 phosphorylation were significantly higher in DN tissues (DN1-DN4) than that in normal control tissues (N1-N4) collected from Department of Nephrology, Shanghai East Hospital as determined by western blot analysis. Densitometric quantification was shown on the bottom. **P < 0.01 vs normal control, n = 4.