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A, structure of the CBL tetramer (PDB entry 1CL1) (11) and the reaction it catalyzes in methionine biosynthesis. B, structure of the ALR dimer (PDB entry 2RJG) (15) and the reaction it catalyzes to provide d-alanine for peptidoglycan biosynthesis. In each structure, the locations of the active sites are highlighted by the PLP cofactor, which is shown in space-filling format.
